\begin{align*}2\sqrt{27} & = 2 \cdot 3\sqrt{3} = 6\sqrt{3} \\3\sqrt{125} & = 3 \cdot 5\sqrt{5} = -15\sqrt{5} \\\sqrt{48} & = 4\sqrt{3} \\5\sqrt{80} & = 5 \cdot 4\sqrt{5} = -20\sqrt{5} \\\end{align*}
Combining like terms:
6\sqrt{3} + 4\sqrt{3} - 15\sqrt{5} - 20\sqrt{5}
= 10\sqrt{3} - 35\sqrt{5}
Answer: 10\sqrt{3} - 35\sqrt{5}