To determine the gradient of the function  F(x, y) = yx  at the point (2, 1), we need to find the partial derivatives with respect to x and y.
Given function:  F(x, y) = yx 
Partial derivative with respect to x: 
 \frac{\partial F}{\partial x} = y 
Partial derivative with respect to y:
 \frac{\partial F}{\partial y} = x 
Now, we evaluate the partial derivatives at the point (2, 1):
 \frac{\partial F}{\partial x} \Bigg|_{(2,1)} = 1 
 \frac{\partial F}{\partial y} \Bigg|_{(2,1)} = 2 
Therefore, the gradient of the function F at the point (2, 1) is given by the vector:
 \nabla F(2, 1) = \Bigg( \frac{\partial F}{\partial x} \Bigg|_{(2,1)}, \frac{\partial F}{\partial y} \Bigg|_{(2,1)} \Bigg) = (1, 2) 
\boxed{\nabla F(2, 1) = (1, 2)}