Question

We plan to test whether the mean mRNA expression level differs between two strains of yeast, for each of 8,000 genes. We will measure the expression levels of each gene, in n samples of strain 1 and m samples of strain 2. We plan to compute a P-value for each gene, using an unpaired two-sample t-test for each gene (the particular type of test does not matter). a) What are the null hypotheses in these tests (in words)? [2] b) If, in fact, the two strains are identical, how many of these tests do we expect to produce a P-value exceeding 1/4? [2]

190

likes
951 views

Answer to a math question We plan to test whether the mean mRNA expression level differs between two strains of yeast, for each of 8,000 genes. We will measure the expression levels of each gene, in n samples of strain 1 and m samples of strain 2. We plan to compute a P-value for each gene, using an unpaired two-sample t-test for each gene (the particular type of test does not matter). a) What are the null hypotheses in these tests (in words)? [2] b) If, in fact, the two strains are identical, how many of these tests do we expect to produce a P-value exceeding 1/4? [2]

Expert avatar
Corbin
4.6
102 Answers
a) The null hypothesis in these tests states that the mean mRNA expression level is the same in both strains of yeast. In other words, there is no difference in the mean expression levels between strain 1 and strain 2 for each gene.

b) If the two strains are identical, we would expect approximately 25% (1/4) of these tests to produce a P-value exceeding 1/4. This is based on the assumption that the P-values follow a uniform distribution under the null hypothesis.

Frequently asked questions (FAQs)
What is the eccentricity of a hyperbola that has a transverse axis of length 8 and a conjugate axis of length 6?
+
What is the constant ratio between any two y-values of the exponential functions f(x) = 10^x and f(x) = e^x?
+
Question: How many ways can a committee of 5 members be selected from a group of 10 people? (
+
New questions in Mathematics
A sample is chosen from a population with y = 46, and a treatment is then administered to the sample. After treatment, the sample mean is M = 47 with a sample variance of s2 = 16. Based on this information, what is the value of Cohen's d?
A=m/2-t isolate t
2(2+2x)=12
I want to divide R$ 2200.00 between Antônio, Beto and Cássia, so that Beto receives half from Antônio and Cássia receives a third of Beto. Under these conditions, how much more will Beto receive than Cássia?
X^2 = 25
7273736363-8
The function g:Q→Q is a ring homomorphism such that g(3)=3 and g(5)=5. What are the values of g(8) and g(9)?
(2x+5)^3+(x-3)(x+3)
The equation of the circle that passes through (5,3) and is tangent to the abscissa axis at x=2 is a.(x-2)^2 (y 3)^2 = 9 b.(x-2)^2 (y-3)^2 = 9 c.(x-2)^2 (y-3)^2 = 4 d.(x-2)^2 (y 1)^2 = 4 e.(x-2)^2 (y-1)^2 = 4
Pedro had 80% of the amount needed to buy a game. Of this amount, you spent 15% on a watch and therefore, you will need to add another R$640.00 to purchase this game. Is the value of the game?
You mix a powder drug with a 4.5ml of liquid to get a reconstituted solution with a concentration of 250mg/ml. The prescribers order is for 500 mg . You will give what ml of the reconstituted solution
Find all real numbers x that satisfy the equation \sqrt{x^2-2}=\sqrt{3-x}
The price per night of a suite at the Baglioni Hotel in Venice is 1896 euros, VAT included. The VAT in Italy is 25%. The hotel gets a return of 10% out of the price VAT included. a) What is the amount of VAT paid by the hotel for one
3 A tree is planted when it is 1.2 m tall. Every year its growth is 3/8 of its previous year's height. Find how tall the tree will grow.
The question is using rule 72 determine Kari wants to save 10,000 for a down payment on a house. Illustrate the difference in years it will take her to double her current 5,000 savings based on 6%, 12% and 18% interest rate .
When Sara was 15 years old, an uncle left her as inheritanceà a sum of 10,000 euros which he invested in a bank that applies the interest rate of 2,5% annual. Today Sara is 18 years and wants to buy a'car, how much she can ò withdraw from the bank?
effectiveness of fiscal and monetary policy under closed and open economies
Given the word WEIRD, determine a four-letter offspring that can be formed with the letters of the word written above
A 20,000 kg school bus is moving at 30 km per hour on a straight road. At that moment, it applies the brakes until it comes to a complete stop after 15 seconds. Calculate the acceleration and the force acting on the body.
A grain silo has a height of 8.8m with a 11.4m diameter. If it is filled 0.5% of it's volume, how much grain (m^3) is stored in the silo? (0 decimal places)