1. Identify the given point $(x_1, y_1) = (2, -5)$ and slope $m = -4$.
2. Use the point-slope form of the line equation:
y - y_1 = m(x - x_1)
3. Substitute $x_1$, $y_1$, and $m$ into the equation:
y - (-5) = -4(x - 2)
4. Simplify the equation:
y + 5 = -4x + 8
5. Rearrange to get the general form $Ax + By + C = 0$:
4x + y - 3 = 0