Your boss asks you to plan the sample size for a randomized, double-blind, controlled trial in the clinical development of a cure for irritable bowl disease. Current standard treatment shall be compared with a new treatment in this trial. The S3-guideline of AWM demonstrated a mean change of the summary score of the validated health related quality of life questionnaire at 8 weeks of 16 with standard deviation 23 under standard treatment. You quote the drop-out rate of 11% from literature (previous phase of clinical development). Your research yielded a clinically important effect of 4 that has been found to be the Minimal Clinically Important Difference (MCID). In order to demonstrate superiority of the new treatment over standard of care, you assume that the change in of the summary score of the validated health related quality of life questionnaire follows a normal distribution, and that the standard deviation is the same for both treatments. How many patientes would one need to recruit for the trial to demonstrate the clinically interesting difference between treatments at significance level 5% with 95% power?
|A hotel in the Algarve had to offer 1 week of vacation to one of its employees as an Easter gift in a random choice. It is known that 80 people work in this hotel unit, 41 of whom are Portuguese and 39 are foreign nationals. There are 14 Portuguese men and 23 foreign women. Using what you know about conditional probability, check the probability that the gift was offered to a Portuguese citizen, knowing that it was a woman.
|Evaluate limx→∞tan−1(x) using that y=tan−1(x) exactly when x=tan(y) . (Hint: Both tan and tan−1 are continuous!)
|The length and breadth of my rectangular vegetable garden is 12,5m and 7,25m respectively. What is the perimeter of the garden?
|A soft drink machine outputs a mean of 23 ounces per cup. The machines output is normally distributed with a standard deviation of 3 ounces. What is the probability of filling a cup between 26 and 28 ounces round your answer to four decimal places
|(24, -7) is on the terminal arm of an angle in standard position. Determine the exact values of the primary trigonometric functions.
|Task 1 angel has 3 quarters 3/8 of a tank of gasoline and Miguel 7/8, who has more gasoline? number line on number line
|Calculate the minimum size of a simple random sample assuming a sampling error of 5% assuming that the population size is 100 elements
|The market for economics textbooks is represented by the following supply and demand equations: P = 5 + 2Qs P = 20 - Qd Where P is the price in £s and Qs and Qd are the quantities supplied and demanded in thousands. What is the equilibrium price?
|3.24 ÷ 82
|Solve the following equation for x in exact form and then find the value to the nearest hundredths (make sure to show your work): 5e3x – 3 = 25
|There are 3 orchards, a, b and c. Orchard a has 60 fewer trees than orchard b orchard c has 3 times as many trees as orchard b. If the three orchards have 430 trees altogether, how many trees does orchard c have?
|viii. An ac circuit with a 80 μF capacitor in series with a coil of resistance 16Ω and inductance 160mH is connected to a 100V, 100 Hz supply is shown below. Calculate 7. the inductive reactance 8. the capacitive reactance 9. the circuit impedance and V-I phase angle θ 10. the circuit current I 11. the phasor voltages VR, VL, VC and VS 12. the resonance circuit frequency Also construct a fully labeled and appropriately ‘scaled’ voltage phasor diagram.
|Consider mixing 150 ml, 0.1M, HCI with 100 ml, 0.2M, KOH solution. Determine the pH of final solution.
|Find I (Intrest) using simple interest formula of 17700 @ 15% for 4 years
|-Please answer to the following questions: What is the price elasticity of demand? Can you explain it in your own words? What is the price elasticity of supply? Can you explain it in your own words? What is the relationship between price elasticity and position on the demand curve? For example, as you move up the demand curve to higher prices and lower quantities, what happens to the measured elasticity? How would you explain that? B-Assume that the supply of low-skilled workers is fairly elastic, but the employers’ demand for such workers is fairly inelastic. If the policy goal is to expand employment for low-skilled workers, is it better to focus on policy tools to shift the supply of unskilled labor or on tools to shift the demand for unskilled labor? What if the policy goal is to raise wages for this group? Explain your answers with supply and demand diagrams. Make sure to properly cite and reference your academic or peer-reviewed sources (minimum 2).
|A small box measures 10 in. by 4 in. by 6 in. high. Find the volume of the box.