Let's use algebra to represent the given information. Let the two numbers be x and y. According to the problem, the sum of two numbers and 16 is equal to 5 times the difference of a number and 6: $x + y + 16 = 5(y - 6)$
Now, we can simplify and solve for the variables. $x + y + 16 = 5y - 30$ $x + y = 5y - 46$ $x = 4y - 46$
Therefore, the variable x is equal to $4y - 46$. \boxed{x = 4y - 46}
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