Solution:
1. Position Andi in the middle seat. There are 5 seats, so Andi will be in the 3^{rd} seat.
2. The remaining 4 friends need to be arranged in the 4 remaining seats.
3. The number of ways to arrange 4 friends in 4 seats is given by 4! (4 factorial).
4. Calculate 4!:
4! = 4 \times 3 \times 2 \times 1 = 24
So, there are 24 different ways for Andi and her 4 friends to sit in a row of 5 seats with Andi in the middle.